METHOD FOR PREPARING METHYL{4,6-DIAMINO-2-1-(2-FLUOROBENZYL)-1H-PYRAZOLO3,4-BPYRIDINE-3-YLPYRIMIDINE-5-YL}METHYLCARBAMATE AND METHOD FOR PURIFYING THE SAME AS MEDICALLY ACTIVE COMPOUND

摘要

PROBLEM TO BE SOLVED: To provide a method for preparing methyl{4,6-diamino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-yl]pyrimidine-5-yl}methylcarbamate.;SOLUTION: There is provided a method for synthesizing an aimed methyl carbamate derivative by reacting 2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-yl]-4,5,6-pyrimidine triamine with methyl chloroformate or dimethyl dicarbonate to obtain a pyrimidinyl derivative as an intermediate via a pyridine free reaction pathway and further reacting with methylation agent Me-X.;SELECTED DRAWING: None;COPYRIGHT: (C)2017,JPO&INPIT