DIRECTED DIFFERENTIATION OF OLIGODENDROCYTE PRECURSOR CELLS TO MYELINATING CELL FATE

摘要

PROBLEM TO BE SOLVED: To provide methods for inducing differentiation of oligodendrocyte progenitor cells to a mature myelinating cell fate with a neurotransmitter receptor modulating agent.;SOLUTION: A therapeutically effective amount of a neurotransmitter receptor-modulating substance selected from a muscarinic receptor antagonist, dopamine receptor antagonist, a histamine receptor antagonist, a β adrenergic receptor modulator and an opioid receptor modulator is administered, thereby stimulating increased myelination of nerves in the subject.;SELECTED DRAWING: Figure 10A;COPYRIGHT: (C)2017,JPO&INPIT