DOSAGE FORM AND USE OF DIETHYLSTILBESTROL FOR TREATING PROSTATE CANCER OR BREAST CANCER

摘要

PROBLEM TO BE SOLVED: To provide pharmaceutical formulations of diethylstilbestrol being an anti-prostate cancer and anti-breast cancer agent avoiding excess cardiovascular side effects such as heart attack, stroke and thrombosis in oral treatment.SOLUTION: A pharmaceutical preparation of the invention is an oral formulation in a form of biodegradable, water soluble film, which comprises an effective amount of diethylstilbestrol, an absorption enhancing agent of which HLB is about 8 to about 16 such as sucrose fatty acid esters, and a water soluble matrix containing at least one of polysorbate or sorbitan fatty acid esters as a nonionic surfactant, and a filming agent selected from a polymer mixture of pullulan and polyvinylpyrrolidone and alginate polymer. By inserting the preparation into the mouth of a patient, the drug is selectively taken in through the mucous membrane avoiding the gastrointestinal tract. The pharmaceutical preparation may contain a second absorption enhancer selected from glycerol, ginger oil, cineole and terpenes.SELECTED DRAWING: None