METHOD FOR TREATING KELOIDS OR HYPERTROPHIC SCARS USING ANTISENSE COMPOUND TARGETING CONNECTIVE TISSUE GROWTH FACTOR (CTGF)

摘要

PROBLEM TO BE SOLVED: To provide a method for preventing formation of, or treating, fibrotic lesions, including skin scars such as keloids and hypertrophic scars.SOLUTION: According to the present invention, the method comprises the step of administering a composition, which inhibits expression of protein involved in fibrosis, to a subject by one or more injections. Here, the composition comprises a modified oligonucleotide, such as a modified antisense oligonucleotide, siRNA, or oligodeoxyribonucleotide, which consists of 12-30 linked nucleosides, at least a 12 nucleobase sequence portion within a region selected from specific nucleotides. According to the present invention, there is also provided dosing of the antisense using an intradermal threading technique.SELECTED DRAWING: Figure 4