ADVERSE SIDE-EFFECTS ASSOCIATED WITH ADMINISTRATION OF ANTI-HYALURONAN AGENT

摘要

PROBLEM TO BE SOLVED: To provide a method for ameliorating an adverse effect of systemic administration of a PEG hyaluronan degrading enzyme to a subject to cope with diseases and disorders associated with accumulation of hyaluronan (hyaluronic acid; HA).SOLUTION: According to the present invention, there is provided a method comprising systemically administering a PEGylated hyaluronan degrading enzyme, particularly a PEGylated hyaluronidase, such as any of the animal or bacterial hyaluronidases, to a subject and administering a pharmaceutical composition including an amount of a glucocorticoid sufficient to ameliorate the adverse effect. According to the present invention, there is also provided a method for treating a hyaluronan-associated disease or condition for single-agent therapy or combination therapy.SELECTED DRAWING: None