METHODS AND COMPOSITIONS FOR STIMULATING NEUROGENESIS AND INHIBITING NEURONAL DEGENERATION USING ISOTHIAZOLOPYRIMIDINONES

摘要

PROBLEM TO BE SOLVED: To provide compositions and compounds that are useful for stimulating neurogenesis and can be used in treatment of diseases and conditions characterized by neuronal loss and reduced neurogenesis including Alzheimer's disease, stroke, traumatic brain injury, traumatic nerve injury, and depression.SOLUTION: The invention provides isothiazolopyrimidine based compounds represented by the formulas in the figure or pharmaceutically acceptable salts, hydrates or solvates thereof, and compositions containing the same.SELECTED DRAWING: Figure 1