Nanoparticles for photodynamic therapy, X-ray induced photodynamic therapy, radiation therapy, chemotherapy, immunotherapy, and any combination thereof

摘要

A metal organic structure (MOF) containing a photosensitizer is described. The MOF may also include a moiety that can absorb x-rays and / or scintillation. Optionally, the photosensitizer or derivative thereof can form the bridging ligand of the present MOF. Further optionally, the present MOF may include inorganic nanoparticles in the MOF cavities or channels, or may be used in combination with inorganic nanoparticles. In photodynamic therapy or X-ray induced photodynamic therapy, MOF and / or inorganic nanoparticles are used, either with or without simultaneous administration of one or more immunotherapeutic agents and / or one or more chemotherapeutic agents A method is also described. [Selection] Figure 1