Antitubercular composition comprising rifampicin, isoniazid, ethambutol and pyrazinamide and method for producing the same

摘要

The present invention is a monolayer tablet for use in the treatment of tuberculosis, comprising: a granule comprising isoniazid, pyrazinamide, ethambutol or a pharmaceutically acceptable salt thereof and at least one granulating binder; The present invention relates to a tablet comprising a mixture of rifampicin and an extragranular additive, wherein all of the granules have a particle size of less than 0.599 mm, preferably less than 0.5 mm, more preferably less than 0.422 mm, and a method for producing the same.