The present disclosure provides a robust, sensitive and specific assay for the detection and measurement of periostin levels in a sample obtained from a human patient having or suspected of having an IL-13 mediated disease or disorder . The present disclosure further provides novel anti-periostin monoclonal antibodies that recognize at least isoforms 1, 2, 3, 4, 7, and 8 of human periostin, and assay kits that include one or more of these antibodies. [Selection figure] None
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