Angiotensin II used alone or in combination for the treatment of hypotension

摘要

The present invention provides, inter alia, a test subject having a high cardiac output shock and subject to treatment with catecholamine at a dose equivalent to at least about 0.2 mcg / kg / min of norepinephrine to reduce the subject's blood pressure. Effective in raising mean arterial pressure (MAP) to 65 mmHg or higher, the catecholamine dose required to maintain a MAP of about 65 mmHg is about 0.05 to 0.2 mcg / kg / min. It relates to a method comprising administering a dose corresponding to norepinephrine, or a dose of angiotensin II that is effective in reducing to a dose corresponding to norepinephrine of about 0.05 mcg / kg / min or less.