Method for monitoring cancer CD4 + T helper type 1 response and immune recovery

摘要

A method for diagnosing or treating a mammalian subject who has developed or is at risk of developing cancer: an antigen presenting cell (APC) or a precursor thereof from a blood sample of said subject and CD4 + T cells, interferon − generating a circulating anti-cancer CD4 + Th1 response that causes secretion of γ (IFN-γ); and detecting the anti-cancer CD4 + Th1 response to determine if the response was suppressed. A method of restoring a HER2-specific CD4 + Th1 immune response in a HER2-positive breast cancer patient in need thereof: to raise the anti-HER2 CD4 + Th1 response of said patient, an immunogenic HER2 MHC class II binding peptide is used. Administering a therapeutically effective amount of a DC vaccine containing pulsed autologous DC (DC vaccination) to the patient; and determining the amount of increase in the response, the anti-HER2 before and after DC vaccination of the patient Measuring a CD4 + Th1 response.