T cell receptor specific for glypican 3 and its use for immunotherapy of hepatocellular carcinoma

摘要

The present invention relates to a T cell receptor specific for glypican 3. The invention further relates to soluble TCR constructs, chimeric TCRs, bispecific antibodies, nucleic acids, expression constructs, and cells comprising the TCR or TCR construct. The invention further provides a TCR as a pharmaceutical or a soluble TCR construct, preferably in the detection, diagnosis, prognosis, prevention and / or treatment of liver cancer, in particular hepatocellular carcinoma, or other cancers expressing GPC3, Or the use of chimeric TCRs or bispecific antibodies. The present invention further relates to a method for detecting, diagnosing, prognosing, preventing and / or treating liver cancer, in particular hepatocellular carcinoma, or other cancers expressing GPC3. The invention further relates to peptides comprising the glypican 3 epitope (s) and their respective nucleic acids, antibodies and compositions encoding them and their use as (peptide) vaccines. The invention further relates to a vaccine comprising the peptide (s).