Nanoparticles loaded with glucocorticoids to prevent corneal allograft rejection and neovascularization

摘要

Dexamethasone sodium phosphate (PLGA) in a matrix such as biodegradable poly (lactic-co-glycolic acid) (PLGA) that is densely coated with a hydrophilic polymer such as PEG or PLURONIC® F127. Particles encapsulating glucocorticoids such as DSP) show sustained release of DSP for up to 7 days in vitro. These nanoparticles can be used to prevent corneal graft rejection or corneal neovascularization.