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Bile acid reuse inhibitors for the treatment of hyperbileemia and cholestatic liver disease
Bile acid reuse inhibitors for the treatment of hyperbileemia and cholestatic liver disease
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机译:胆汁酸再利用抑制剂治疗高胆汁血症和胆汁淤积性肝病
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摘要
Provided herein are methods of treating or ameliorating hypercholemia or a cholestatic liver disease by administering to an individual in need thereof a therapeutically effective amount of an Apical Sodium-dependent Bile Acid Transporter Inhibitor (ASBTI) or a pharmaceutically acceptable salt thereof. Also provided are methods for treating or ameliorating a liver disease, decreasing the levels of serum bile acids or hepatic bile acids, treating or ameliorating pruritis, reducing liver enzymes, or reducing bilirubin comprising administering to an individual in need thereof a therapeutically effective amount of ASBTI or a pharmaceutically acceptable salt thereof.
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