Lovaplatin crystal, preparation method and drug application

摘要

The present invention extends to new crystals A, B and F of lovaplatin and methods for their preparation and drug applications. Among them, the melting point of the donkey platin crystal A is Tm. p. = 220 ± 5 ° C., obtained by adding donkey platin trihydrate to the suspension crystal solvent, melting point of donkey platin B being Tm. p. = 230 ± 5 ° C., and obtained by drying the lobaplatin trihydrate through volatilization of the solvent, volatilizing at room temperature after adding the solvent into the lobaplatin dihydrate, or crystallization of the crystals. The melting point of Lovaplatin crystal form F is Tm. p. = 229 ± 5 ° C., stir until the solid is dissolved at room temperature through addition of methanol or ethanol into the donkey platin dihydrate, remove the insoluble matter, and slowly add the organic solvent, After the crystals are precipitated, the crystals are separated out and obtained after drying. Compared to the existing lovaplatin and lovaplatin trihydrate, these lovaplatin crystals A, B and F have better stability and solubility, and can be used for preparation, storage and use of various types of drug preparations Suitably, it can be used more often for the treatment of cancer diseases such as breast cancer, small cell lung cancer or chronic granulocytic leukemia. [Selection] Figure 2