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Non-invasive method for specific 3D detection, visualization and / or quantification of endogenous phosphors such as melanin in living tissue
Non-invasive method for specific 3D detection, visualization and / or quantification of endogenous phosphors such as melanin in living tissue
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机译:非侵入性方法,用于3D检测,可视化和/或定量活体组织中黑色素等内源性荧光粉
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摘要
Method for detection, quantification and/or visualization of an endogenous fluorophore, in a biological tissue, the method comprising the steps consisting in: a) acquiring, after multiphoton excitation, a set of successive three- dimensional or two-dimensional images providing information on the decrease over time in the fluorescence signals in the sample, b) determining by processing these images, by performing a linear regression of the logarithm of the fluorescence signals, the spatial distribution in the sample of the slopes of said linear regression, and c) generating information on the presence and/or the volume density or surface density of a fluorophore in the sample at least on the basis of this spatial distribution, the fluorophore being melanin.
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