Method of improving the stability of compositions containing flavin-binding glucose dehydrogenase

摘要

PROBLEM TO BE SOLVED: To provide a composition containing mucor-derived flavin-binding glucose dehydrogenase (FAD-GDH) with sufficient thermal stability.SOLUTION: An FAD-GDH-containing composition includes one or more kinds of coexistent compounds selected from aminoguanidine, arginine, lysine, ornithine, glycine, glutamic acid, citraconic acid, glycolic acid, tartaric acid, malic acid, citric acid, gluconic acid, and salt compounds thereof, trehalose, xylitol, sucrose, α-cyclodextrin, sodium chloride, potassium chloride, sodium sulfate, potassium sulfate, and ammonium sulfate. The composite can reduce deactivation of FAD-GDH when a glucose-measuring reagent, glucose assay kit, and glucose sensor are prepared and stored, and decrease the amount of use of FAD-GDH, as well as can enhance thermal and storage stability of the measuring reagent, the assay kit and the sensor, and improve the measurement accuracy.