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Mannosidase capable of uncapping and demannosylating phosphorylated N-glycans from mannose-1-phospho-6-mannose linkages and methods for promoting glycoprotein uptake by mammalian cells
Mannosidase capable of uncapping and demannosylating phosphorylated N-glycans from mannose-1-phospho-6-mannose linkages and methods for promoting glycoprotein uptake by mammalian cells
The invention provides mannosidases capable of uncapping mannose-1-phospho-6-mannose moieties and demannosylating phosphorylated N-glycans, methods of using such mannosidases, glycoproteins produced using the methods, as well as methods of facilitating mammalian cellular uptake of glycoproteins.
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