PARP9 and PARP14 as key regulators of macrophage activation

摘要

The present invention relates to compositions and methods, such as small molecules, RNAi and antibodies, for inhibiting macrophage activation through modulating PARP9 and / or PARP14 expression or activity. Modulating the expression and / or activity of PARP9 and / or PARP14 allows activation of monocytes or macrophages M1 and inhibition of inflammation. For treating, preventing and / or managing a condition where it is known or likely that undesirable excessive or persistent inflammation contributes to the onset, occurrence and / or progression of the condition Inhibition of unwanted excessive or persistent inflammation found in humans.