Uronic acid derivatives exhibiting an expression level increasing effect of longevity genes Sirt1 that applies aging culture

摘要

PROBLEM TO BE SOLVED: To provide an uronic acid derivative which shows longevity gene Sirt1 activating action adapting health care culture, and to provide a production method thereof.SOLUTION: The target uronic acid derivative comprises a tripeptide consisting of arginine, threonine, and asparagine, and uronic acid. The uronic acid is bound to the arginine of the tripeptide and shows longevity gene Sirt1 activating action. This production method comprises adding branched cyclodextrin into the fermented solution obtained by fermenting unpolished rice, black rice, red-kerneled rice, barley, rice cake wheat, pigeon wheat, foxtail millet, Japanese millet, millet, Sorghum bicolor, soybean, black soybean, adzuki bean, and corn with Bacillus natto, performing protease treatment, subsequently performing alkali reduction of the filtered filtrate.