首页>
外国专利>
BIOMARKER FOR COGNITIVE DYSFUNCTION DISEASES, AND METHOD FOR DETECTION OF COGNITIVE DYSFUNCTION DISEASES USING THE BIOMARKER
BIOMARKER FOR COGNITIVE DYSFUNCTION DISEASES, AND METHOD FOR DETECTION OF COGNITIVE DYSFUNCTION DISEASES USING THE BIOMARKER
展开▼
机译:用于认知功能障碍疾病的生物标记,以及使用该生物标记物检测认知功能障碍的方法
展开▼
页面导航
摘要
著录项
相似文献
摘要
The present invention aims to provide methods to detect cognitive impairment including mild cognitive impairment and Alzheimer disease by using a protein or its partial peptide that differs in presence or absence, or in quantity between non-cognitive impairment and patients with cognitive impairment and further aims to present biomarkers comprising said protein and said partial peptide to be used to detect cognitive impairment including Alzheimer disease or mild cognitive impairment. Specifically, a biomarker for diagnosis of psychiatry disease or cognitive impairment comprising protein fragment or peptide of not less than 5 amino acid residues arising from at least one protein or peptide selected from the group of proteins consisting of amino acid sequence expressed by SEQ ID NOS: 1, 3, 5, 7, 9, 11, 13, 15, 17, 19, 21, 23, and 25 and selected from the group of partial peptide in these proteins consisting of amino acid sequence expressed by SEQ ID NOS: 2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24, 26, and 27. And further aims to provide diagnostic method using these biomarker.
展开▼
机译:本发明旨在提供通过使用在非认知障碍和患有认知障碍的患者之间存在或不存在或数量上不同的蛋白质或其部分肽来检测包括轻度认知障碍和阿尔茨海默氏病的认知障碍的方法,并且进一步旨在提出了包含所述蛋白质和所述部分肽的生物标志物,用于检测包括阿尔茨海默氏病或轻度认知障碍在内的认知障碍。具体而言,用于诊断精神病或认知障碍的生物标志物,其包含由至少一种选自由SEQ ID NOS所示的氨基酸序列组成的蛋白质组中的蛋白质或肽产生的不少于5个氨基酸残基的蛋白质片段或肽: 1、3、5、7、9、11、13、15、17、19、21、23和25,并选自这些蛋白质中由SEQ ID NOS:2表示的氨基酸序列组成的部分肽4、6、8、10、12、14、16、18、20、22、24、26和27。并且进一步旨在提供使用这些生物标记物的诊断方法。
展开▼