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METHOD TO IMPROVE THE IDENTIFICATION, QUANTIFICATION AND SPATIAL LOCALIZATION OF MULTIPLY CHARGED MOLECULES IN BIOLOGICAL SAMPLES USING ION MOBILITY INFORMATION
METHOD TO IMPROVE THE IDENTIFICATION, QUANTIFICATION AND SPATIAL LOCALIZATION OF MULTIPLY CHARGED MOLECULES IN BIOLOGICAL SAMPLES USING ION MOBILITY INFORMATION
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机译:利用离子迁移率信息改善生物样品中带电荷分子的鉴定,定量和空间定位的方法
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摘要
Described herein is a method of analyzing a sample including molecules having two or more possible sites for ionization comprising: 1) separating ionized molecules of the sample according to ion mobility of the ionized molecules, and 2) analyzing the ionized molecules using mass spectrometry. Additionally described herein is a method of diagnosing and/or determining the progression of a disease or disorder associated with gangliosides and/or cardiolipins in a subject comprising: 1) separating ionized molecules in a biological sample from the subject according to ion mobility of the ionized molecules, and 2) analyzing the ionized molecules using mass spectrometry to identify and quantify gangliosides and/or cardiolipins in the sample.
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