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Antigen-specific central-memory T cell preparations having high CD4+ fraction
Antigen-specific central-memory T cell preparations having high CD4+ fraction
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机译:具有高CD4 +分数的抗原特异性中央记忆T细胞制剂
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摘要
The invention relates to a method for generation of T cell preparations that are specific for at least one target antigen, comprising the steps of expanding lymphoid cells in vitro in the presence of a target antigen or peptide fragments thereof in an expansion step, isolating cells that secrete interferon gamma and culturing, the cells in the presence of interleukin 2 and interleukin 7 and either an inhibitor of the mTOR Complex 1, or in the presence of an inhibitor of IL-2/IL-2R interaction. The invention further relates to preparations obtained by the method of the invention.
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