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Methods for treatment of CD14-mediated disorders and responses
Methods for treatment of CD14-mediated disorders and responses
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机译:CD14介导的疾病和反应的治疗方法
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摘要
A method for blocking, inhibiting and/or decreasing cluster of differentiation 14 (CD14) function, CD14-mediated cellular response and/or treating CD14-mediated pathological conditions is disclosed. The method comprises administering to a subject in need thereof a pharmaceutical composition comprising: (a) a therapeutically effective amount of a recombinant protein comprising an amino acid sequence that is at least 80% identical to SEQ ID NO: 1, wherein the recombinant protein does not comprises a lectin-like domain 1 of a human thrombomodulin; and (b) a pharmaceutically acceptable vehicle, carrier, diluent, excipients, and/or salt.
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机译:公开了一种阻断,抑制和/或降低分化14(CD14)功能簇,CD14介导的细胞应答和/或治疗CD14介导的病理状况的方法。该方法包括向有需要的受试者施用药物组合物,该药物组合物包含:(a)治疗有效量的重组蛋白,该重组蛋白包含与SEQ ID NO:1至少80%相同的氨基酸序列。不包含人血栓调节蛋白的凝集素样结构域1; (b)药学上可接受的媒介物,载体,稀释剂,赋形剂和/或盐。
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