Compounds for inhibiting drug-resistant strains of HIV-1 integrase

摘要

A method of inhibiting drug-resistant HIV-1 integrase in a subject comprising administering to a subject in need thereof a therapeutically effective amount of a compound of formula I, or a pharmaceutically acceptable salt or ester thereof, having a structure of:; wherein X is N, C(OH), or CH;Y is H or OH;each of Z¹-Z⁵ is independently H or halogen;R⁴ is H, OH, NH₂, NHR⁸, NR⁸R⁹ or R⁸;R⁵, R⁶, and R⁷ is each independently H, halogen, OR⁸, R⁸, NHR⁸, NR⁸R⁹, CO₂R⁸, CONR⁸R⁹, SO₂NR⁸R⁹, or R⁵ and R⁶ together with the carbon atoms to which R⁵ and R⁶ are attached form an optionally-substituted carbocycle or optionally-substituted heterocycle; andR⁸ and R⁹ is each independently H, optionally-substituted alkyl, optionally-substituted alkenyl, optionally-substituted alkynyl, optionally-substituted aryl, optionally-substituted cycloalkyl, optionally-substituted cycloalkylene, optionally-substituted heterocycle, optionally-substituted amide, optionally-substituted ester, or R⁸ and R⁹ together with the nitrogen to which R⁸ and R⁹ are attached form an optionally-substituted heterocycle.