COMPOSITIONS AND METHODS THAT INVOLVE PROTEIN SCAFFOLDS THAT SPECIFICALLY BIND TO HEPATOCYTE GROWTH FACTOR RECEPTOR

摘要

This disclosure describes a non-naturally occurring protein scaffold that specifically binds to hepatocyte growth factor receptor (MET) and methods of using such protein scaffolds. Generally, the protein scaffold includes a frame and at least one loop region that specifically binds hepatocyte growth factor receptor (MET). The frame generally includes a plurality of structural domains that include at least one β structure or at least one a helix. The loop region generally includes an amino acid sequence that varies from a naturally-occurring loop region by at least one amino acid deletion, amino acid substitution, or amino acid addition.