;where R1 in each occurrence is independently H, or C1-C4 alkyl; R2 is a nullity or CH—CH3, R3 is a nullity or C(O)—R6—NH; R6 is C2-C6 alkyl, (CH2CH2—O)n, or (CH(OH)CH2)n; n is an integer of between 1 and 4; R4 is a nullity or NH—R6—C(O); and R5 is a moiety capable of crossing the blood brain barrier and is as a free compound serotonin, dopamine, blood brain barrier (BBB) peptide, membrane translocating peptide, TAT peptides, endocannabinoids 1 & 2, bradykinin, beta-endorphin, bombesin, calcitonin, cholecystokinin, an enkephalin, dynorphin, insulin, gastrin, substance P, neurotensin, glucagon, secretin, somatostatin, motilin, vasopressin, oxytocin, prolactin, thyrotropin, an angiotensin, galanin, neuropeptide Y, thyrotropin-releasing hormone, gonadotropnin-releasing hormone, growth hormone-releasing hormone, luteinizing hormone, vasoactive intestinal peptide transferrin, glucosyl ester, lactic acid, leucine, tryptophan, glutamic acid."/>
AMANTADINE, MEMANTINE, AND RIMANTADINE CONJUGATES AND A PHARMACEUTICAL COMPOSITION FOR TREATMENT OF NEURONAL DISORDERS
A compound is provided that has the formula (II):; ;where R1 in each occurrence is independently H, or C1-C4 alkyl; R2 is a nullity or CH—CH3, R3 is a nullity or C(O)—R6—NH; R6 is C2-C6 alkyl, (CH2CH2—O)n, or (CH(OH)CH2)n; n is an integer of between 1 and 4; R4 is a nullity or NH—R6—C(O); and R5 is a moiety capable of crossing the blood brain barrier and is as a free compound serotonin, dopamine, blood brain barrier (BBB) peptide, membrane translocating peptide, TAT peptides, endocannabinoids 1 & 2, bradykinin, beta-endorphin, bombesin, calcitonin, cholecystokinin, an enkephalin, dynorphin, insulin, gastrin, substance P, neurotensin, glucagon, secretin, somatostatin, motilin, vasopressin, oxytocin, prolactin, thyrotropin, an angiotensin, galanin, neuropeptide Y, thyrotropin-releasing hormone, gonadotropnin-releasing hormone, growth hormone-releasing hormone, luteinizing hormone, vasoactive intestinal peptide transferrin, glucosyl ester, lactic acid, leucine, tryptophan, glutamic acid.
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机译：提供具有式（II）的化合物： ;其中每次出现的R 1 独立地为H或C 1 -C 4 烷基; R 2 是无效或CH-CH 3 ，R 3 是无效或C（O）-R 6 —NH; R 6 是C 2 -C 6 烷基，（CH 2 CH 2 —O） n 或（CH（OH）CH 2 ） n ; n为1至4之间的整数; R 4 是无效值或NH-R 6 -C（O）;和R 5 是能够穿过血脑屏障的部分，是游离的血清素，多巴胺，血脑屏障（BBB）肽，膜移位肽，TAT肽，内源性大麻素1和2，缓激肽，β-内啡肽，蛙皮素，降钙素，胆囊收缩素，脑啡肽，强啡肽，胰岛素，胃泌素，P物质，神经降压素，胰高血糖素，促胰液素，促生长素抑制素，胃动素，血管加压素，催产素，催乳素，促甲状腺激素，血管紧张素，血管紧张素促甲状腺激素释放激素，促性腺激素释放激素，生长激素释放激素，黄体生成激素，血管活性肠肽转铁蛋白，葡萄糖基酯，乳酸，亮氨酸，色氨酸，谷氨酸。
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