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Substituted biphenyl analogues as dual inhibitors of aromatase and sulfatase

机译:取代联苯类似物作为芳香化酶和硫酸酯酶的双重抑制剂

摘要

The present invention relates to new biphenyl derivatives of formula; embedded image These compounds acting as aromatase and sulfatase inhibitors, they are particularly useful for treating pathological conditions or diseases in which aromatase and sulfatase are involved. Moreover, the present invention provides processes for the preparation of these compounds. The invention also relates to pharmaceutical compositions containing said products and their use for the preparation of a medicament, in particular for the treatment of diseases characterized by aromatase and sulfatase activity such as hormone-dependent cancers.
机译:本发明涉及式的新联苯衍生物。 “嵌入式图像” 这些化合物充当芳香化酶和硫酸酯酶的抑制剂,它们对于治疗涉及芳香化酶和硫酸酯酶的病理状况或疾病特别有用。而且,本发明提供了制备这些化合物的方法。本发明还涉及含有所述产物的药物组合物及其在制备药物中的用途,特别是用于治疗以芳香酶和硫酸酯酶活性为特征的疾病,例如激素依赖性癌症。

著录项

  • 公开/公告号US9682941B2

    专利类型

  • 公开/公告日2017-06-20

    原文格式PDF

  • 申请/专利权人 ESTRYX PHARMA LIMITED;

    申请/专利号US201315104884

  • 申请日2013-12-31

  • 分类号C07D401/12;C07D235/16;A61K31/4184;A61K31/4188;A61K31/4192;A61K31/444;C07D249/18;C07D235/06;C07D401/06;C07D235/22;C07D403/06;C07D471/04;C07D403/12;

  • 国家 US

  • 入库时间 2022-08-21 13:45:05

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