Hyperbranched amino acid-based poly(ester urea)s for regenerative medicine and drug delivery

摘要

One or more embodiments of the present invention provide a hyperbranched amino-acid-based PEU polymer for use in regenerative medicine and/or drug delivery applications has tunable mechanical and thermal properties, but is sufficiently stable to permit such things as ethyloxide sterilization without degradation and/or significant loss of function. These hyperbranched amino acid-based poly(ester urea) (PEU) by interfacial polycondensation between linear and branched amino acid-based polyester monomers and a urea forming material such as trisphosgene or phosgene. By controlling the amount of branched monomer incorporated into the copolymer, the mechanical properties and water uptake abilities of the resulting hyperbranched amino acid-based PEUs may be tuned. The hyperbranched PEUs nanofibers are sterilizable with ETO and are stable for long periods of ETO sterilization, elevated temperature and exposure to aqueous environments. In various embodiments, these hyperbranched amino acid-based PEUs are also biodegradable and can be formed into fibers.