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LABEL FREE BIOSENSORS, GRAM-NEGATIVE BACTERIA DETECTION, AND REAL-TIME AND END POINT DETERMINATION OF ANTIBIOTIC EFFECTS
LABEL FREE BIOSENSORS, GRAM-NEGATIVE BACTERIA DETECTION, AND REAL-TIME AND END POINT DETERMINATION OF ANTIBIOTIC EFFECTS
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机译:标签免费生物传感器,革兰氏阴性细菌检测以及抗生作用的实时和终点测定
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摘要
Real-time and end point determination of antibiotic effects are disclosed herein. In one example, a surface of a label free biosensor is exposed to a sample including a gram-negative bacteria. A frequency and/or a current of the biosensor is then allowed to reach a constant value. The surface of the biosensor is then exposed to an antibiotic. Using the biosensor, i) a frequency change versus time and a damping resistance versus time, or ii) a current versus voltage or the current versus time at a fixed potential, or iii) both i and ii are then measured. The frequency change versus time and the damping resistance versus time and/or the current versus voltage or the current versus time are correlated to determine an effect of the antibiotic on the gram-negative bacteria. Examples of the label free biosensors and methods for detecting gram-negative bacteria using the label free biosensors are also disclosed.
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