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Clostridium difficile toxin-based vaccine

机译：艰难梭菌毒素疫苗

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摘要

The present invention relates to recombinant fragments of C. difficile TcdA and TcdB that may be used in the development of vaccines against C. difficile associated disease. More particularly it relates to combinations comprising a ToxB-GT antigen and a TcdA antigen or a ToxA-GT antigen and a TcdB antigen.

机译：本发明涉及I C的重组片段。艰难的 TcdA和TcdB，可用于开发针对 C的疫苗。困难的相关疾病。更具体地，本发明涉及包含ToxB-GT抗原和TcdA抗原或ToxA-GT抗原和TcdB抗原的组合。 展开▼

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公开/公告号US9694063B2

专利类型

公开/公告日2017-07-04

原文格式PDF

申请/专利权人 GLAXOSMITHKLINE BIOLOGICALS SA;
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申请/专利号US201214363387

发明设计人 MARIA SCARSELLI;MARIAGRAZIA PIZZA;ROSANNA LEUZZI;MARIA ARICO;MANUELE MARTINELLI;GILLIAN DOUCE;
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申请日2012-12-07

分类号A61K39/08;C07K14/33;A61K39;

国家 US

入库时间 2022-08-21 13:42:48

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3. Toll-Like Receptor 5-Dependent Immunogenicity and Protective Efficacy of a Recombinant Fusion Protein Vaccine Containing the Nontoxic Domains of Clostridium difficile Toxins A and B and Salmonella enterica Serovar Typhimurium Flagellin in a Mouse Model of Clostridium difficile Disease [J] . Chandrabali Ghose, Janneke M. Verhagen, Xinhua Chen, Infection and immunity . 2013,第6期

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6. Plasmid DNA as a Platform for the Development of Prophylactic and Therapeutic Vaccines Against Clostridium difficile in Aging Models of Disease [D] . Ramamurthi, Arjun 2017

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