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Use of naringenin in preparing drugs for preventing and/or treatment abdominal aortic aneurysm
Use of naringenin in preparing drugs for preventing and/or treatment abdominal aortic aneurysm
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机译:柚皮苷在制备预防和/或治疗腹主动脉瘤的药物中的用途
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摘要
Naringenin is used for preparing products for preventing and/or treating abdominal aortic aneurysms. The products include drugs and/or health care products. The products were tested in two clinically associated abdominal aortic aneurysm disease models: using angiotensin II (1000 ng/kg/min) through subcutaneous submerging pump to induce ApoE knockout mice; and using calcium phosphate (0.5 M) to daub the abdominal aortas of locally induced C57 mice with abdominal aortic aneurysms. Experiments demonstrate that orally administered naringenin can significantly inhibit the onset and development of an abdominal aortic aneurysm in the CaPO4 daubed and AngII submerging pump induced mice. Thus, naringenin can be used in the treatment of patients with abdominal aortic aneurysms.
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机译:柚皮苷用于制备预防和/或治疗腹主动脉瘤的产品。产品包括药品和/或保健产品。产品在两种临床相关的腹主动脉瘤疾病模型中进行了测试:通过皮下浸没泵使用血管紧张素II(1000 ng / kg / min)诱导ApoE基因敲除小鼠;然后用磷酸钙(0.5 M)涂抹局部诱导的C 57 B>腹主动脉瘤小鼠的腹主动脉。实验证明,口服柚皮苷可以显着抑制CaPO 4 Sub>涂抹和AngII浸没泵诱导小鼠的腹主动脉瘤的发作和发展。因此,柚皮苷可以用于治疗腹主动脉瘤患者。
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