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Pentacyclic pyridoindolobenzob,ediazepines and thiazepines for treating CNS disorders
Pentacyclic pyridoindolobenzob,ediazepines and thiazepines for treating CNS disorders
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机译:五环吡啶并吲哚并苯并[b,e]二氮杂和硫氮平治疗中枢神经系统疾病
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摘要
The present invention discloses pyridoinolobenzo[b,e]diazepine and thiazepine derivatives of Formula 1,; wherein X is NR10, S, S(O), or S(O)2. Y is a single bond or no bond. A and B are independently (CH2)m and (CH2)n respectively; and the subscripts ‘m’ and ‘n’ independently vary from 1 to 4. R1 to R9 are various electron donating, electron withdrawing, hydrophilic, or lipophilic groups selected to optimize the physicochemical and biological properties of compounds of Formula I.
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