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Method for increasing the efficiency of double-strand-break induced mutagenesis
Method for increasing the efficiency of double-strand-break induced mutagenesis
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机译:提高双链断裂诱变效率的方法
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摘要
The present invention relates to a method for increasing double-strand-break induced mutagenesis at a genomic locus of interest in a cell, thereby giving new tools for genome engineering, including therapeutic applications and cell line engineering. More specifically, the present invention concerns the combined use of TALEN or meganucleases with TREX2, especially under the form of single-chain proteins.
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