Methods and Biomarkers to predict the effectiveness and Evaluation of treatment with Ox40 agonist

摘要

By measuring the expression level of one or more biologists, this study provides a method to predict the response of cancer patients to OX40. Methods for controlling drug addiction or drug resistance are also provided.By measuring the expression level of one or more biologists, OX40 pleasure therapy was carried out. It also provides methods related to the treatment or delay of cancer progression in patients, which can be delivered to patients by the acceptors with an effective dose of OX40. Previous pageAll of these methods have specific biological ark. Requirement 1: a method for predicting the response ability of cancer patients to OX40 painkiller treatment, including: (a) measuring the performance level of one or more genes in a sample, which includes leukemia obtained from one experimental subject, and selecting one or more gene markers. A group composed of CD8a, cd8b, h2-d, CTLA4, CD64, CXCL9, Ifng, ido1, gzma, gzmB, PRF1, pdca1, klrk1, PPRC, CXCL1, itgam and il7r;And (b) classify the experimental object as an object that can or cannot respond according to the expression level of one or more genes in the sample. Compared with a reference object, the expression level of one or more genes is higher than the reference value, indicating that Subjects may be able to receive OX40 painkillers