Methods of Diagnosis and Therapy for Disorders mediated by il-33, composition, antagonist binding of il-33 Axis

摘要

Methods of treating a patient suffering from a disorder mediated by il-33, such as Asthma, comprising administering to the patient an antagonist binding Axis il-33 Gene il1rl1 based on Genotype.Methods for determining if a patient has an increased risk of impairment mediated by il-33 and his time with methods for determining if a patient suffering from a disturbance that is candidate to respond to treatment with an antagonist binding Axis il-33, based on Genotype il1rl1 Gene.Claim 113: the method of any of claims 1, 4, 13, 16, 25, 28, 37, 40, 49, 52, 61, 64, 73, 81, 91, 92, 96, 97, 100, where the antagonist binding Axis il-33 is administered in combination with an antagonist binding Tryptase - Shaft B, a homologous Molecule Chemoattractant receptor expressed on Th2 Cells (CRTH2 antagonist binding)An antagonist binding interleukin (IL - 13 - 33), an antagonist binding of interleukin-17 (il-17), an antagonist JAK1 and / or an antagonist binding Interleukin 5 (il-5).Claim 114: the method of any one of claims 1, 3, 13, 15, 25, 27, 37, 39, 49, 51, 61, 63 - 73 and 75 - 112 - 92 and 93, in which the antagonist binding Axis il-33 is an antagonist binding il-33 ST2, an antagonist binding, or an antagonist binding I L - 1RAcP.