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Local advanced or metabolic breast cancer treatment with PD-1 axis and Taxas diagonal

机译:PD-1轴和Taxas对角线用于局部晚期或代谢性乳腺癌治疗

摘要

1. Claim 1: a method of treating or delaying the spread of locally advanced or metabolic breast cancer in an individual, including the effective management of antibody positive persons combined with human PD-1 axis and steroids. Claim 40: a method of treating or delaying a person's locally advanced or metabolic breast cancer, which includes a dose method including a treatment cycle to treat the individual on the 1st and 15th day of each cycle, An antibody that binds to the human PD-1 axis at a dose of about 840 Mg on days 1, 8, and 15 of each cycle,Taxonomic animals with a dose of about 100 mg / m,Repeat every 28 days Requirement 85: a method of enhancing immune function in people with locally advanced or metabolic breast cancer, including a dose method including a treatment cycle, to treat individuals on the 1st and 15th day of each cycle, 1. The target country combined with human PD-1 axis at a dose of about 840 mg, and classified animals at a dose of about 100 mg / m2 at 1, 8 and 15 days of each cycle,Each cycle is repeated every 28 days. Requirement 99: the use of human PD-1 axis combination antagonists to treat or delay the development of a person's local advanced or metabolic breast cancer, which consists of human PD-1 axis combination antagonists and alternative acceptable drug carriers,Treatment includes the use of drugs, plus an ingredient that includes an alternative drug and an acceptable carrier. Requirement 118: consists of a target country combined with the PD-1 human body axis and a local advanced or metabolic breast cancer drug carrier that can be selected for treatment or delayed treatment of a person. Treatment includes the management of this component Combined with the second component,The second component includes an alternative tax and a drug acceptable carrier. Item 137: a drug package that includes protesters on the PD-1 axis and an optional acceptable drug carrier, There is also a specification, which includes a description of drug management, as well as a component, which includes a classification and a drug acceptable optional carrier to treat or delay the development of a person's locally advanced or metabolized breast cancer.
机译:1.一种治疗或延迟个体中局部晚期或代谢性乳腺癌扩散的方法,包括有效治疗与人PD-1轴和类固醇结合的抗体阳性患者。 40.一种治疗或延迟人的局部晚期或代谢性乳腺癌的方法,其包括剂量方法,所述剂量方法包括在每个周期的第1天和第15天治疗个体的治疗周期,所述抗体结合人PD- 1个轴,每个周期的第1、8和15天约840 Mg剂量,动物类动物约100 mg / m的剂量,每28天重复一次要求85:一种增强局部免疫力的方法晚期或代谢性乳腺癌,包括包括治疗周期在内的剂量方法,用于在每个周期的第1天和第15天治疗个体。1.目标国家/地区与人类PD-1轴组合,剂量约为840 mg,并进行了分类在每个周期的第1、8和15天,动物的剂量约为100 mg / m2,每28天重复一次。要求99:使用人类PD-1轴联合拮抗剂治疗或延缓人的局部晚期或代谢性乳腺癌的发展,其中包括人类PD-1轴联合拮抗剂和其他可接受的药物载体,治疗包括使用药物,以及包含替代药物和可接受载体的成分。要求118:由与PD-1人体轴相结合的目标国家和可以选择用于治疗或延迟治疗的当地晚期或代谢性乳腺癌药物载体组成。治疗包括对这一部分的管理与第二部分相结合。第二部分包括替代税和药物可接受的载体。第137条:药物包装,其中包括PD-1轴上的示威者和可选的可接受的药物载体,还有一个规范,其中包括对药物管理的描述,以及一个组成部分,包括分类和可接受的药物治疗或延迟人的局部晚期或代谢性乳腺癌发展的可选载体。

著录项

  • 公开/公告号AR105027A1

    专利类型

  • 公开/公告日2017-08-30

    原文格式PDF

  • 申请/专利权人 GENENTECH INC.;

    申请/专利号AR2016P101806

  • 发明设计人

    申请日2016-06-16

  • 分类号C07K16/30;A61K39/395;A61P35/04;

  • 国家 AR

  • 入库时间 2022-08-21 13:40:59

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