regulation of receptor expression by distribution of artificial transcription factors

摘要

patent specification: "regulation of receptor expression by distribution of artificial transcription factors". The present invention relates to an artificial transcription factor comprising a polydactyl zinc finger protein that specifically targets a receptor gene promoter fused to an inhibitor or activator protein domain, a nuclear localization sequence and a protein transduction. in particular examples, such receptor gene promoters regulate expression of the endothelin receptor a, endothelin receptor b, toll 4 receptor or high affinity ige receptor. Artificial transcription factors directed to endothelin receptors a or b are useful in the treatment of endothelin-modulated diseases such as cardiovascular diseases, and in particular eye diseases, eg retinal vein occlusion, retinal artery occlusion, edema macular, optic neuropathy, central serous chorioretinopathy, retinitis pigmentosa, hereditary leber optic neuropathy, and others. Artificial transcription factors directed to the toll 4 receptor or ige receptor are useful for the treatment of autoimmune and other disorders and allergic disorders, respectively.