Process of synthesis of new citosporona and analogues and their applications as adjuvant therapy against cancer, potentiating the effects of cyclophosphamide.

摘要

Process of synthesis of new citosporona and analogues and their applications as adjuvant therapy against cancer, potentiating the effects of cyclophosphamide. One of the main problems in the development of new drugs for the treatment of cancer is the limited specificity of the compounds, which also affect the tumour cells does not.So a large number of research search in natural sources and in the synthesis of compounds, alternative products that can effectively achieve the cancer cells, without causing undesirable effects on healthy cells that are capable of potentiating effects or chemotherapeutic drugs and reduction Today at the side effects of this therapy.The results suggest that the compounds designed and synthesized have therapeutic potential as, according to the design developed, does not cause genetic alterations and biochemical, and the tissue appear to be transient.In addition, the lipids has expanded the mutagenic effect of cyclophosphamide which may have determined the increase of apoptosis, and highlight its capabilities imunomodulatu00f3ria. Therefore, ams049, ams35aa and ams35bb may be indicated as important candidates for adjuvant chemotherapy.