Liquid crystalline systems based on vegetable fat Murumuru (astrocaryum Murumuru Mart.) for sustained release of drug in skin and cavities lined by mucous membrane.

摘要

Liquid crystalline systems based on vegetable fat Murumuru (astrocaryum Murumuru Mart.) for sustained release of drug in skin and cavities lined by mucous membrane.The present invention describes the composition of a new liquid crystalline system for the sustained release of active substances of the hydrophilic character and / or lipophilic skin and in cavities lined by mucous membranes, characterized by containing, as major ingredient the vegetable fat Murumuru (astrocaryum Murumuru Mart.).The dosage forms semissu00f3lidas conventional creams, ointments, gels and lotions are prone to rapid erosion and physical disruption due to the constant fluid flow at the site of application and low bioavailability of the active substance with the resulting ineffectiveness Therapy.The new modified release systems, examples of liquid crystals, may increase the bioavailability of active substances, due to its physical properties, appropriate corroborating with the reduction of adverse effects and frequency of use of medicines.In view of this, the strategy aims at the employment of vegetable fat extracted from the seeds of Murumuru (astrocaryum Murumuru Mart.) as a biodegradable and biocompatible to the development of liquid crystalline systems for sustained release of a S active, adding value to the raw materials of the Amazon region through the promotion of technology and innovation.