combination therapy using belinostat and trabectedin

摘要

patent summary: "combination therapy using belinostat and trabectedin". The present invention relates to therapies for the treatment of diseases and disorders that are mediated by histone deacetylase (hdac) (e.g., cancer, including, for example, ovarian cancer, soft tissue sarcoma, osteosarcoma, etc.) that employ a combination (e.g., a synergistic combination) of (a) belinostat, or a salt, hydrate, or solvate thereof, and (b) trabectedin, or a salt, hydrate, or solvate thereof.