rapid disintegrating solid dosage form formulation comprising functionalized calcium carbonate and method of manufacture thereof

摘要

"rapid disintegrating solid dosage form formulation comprising functionalized calcium carbonate and method of manufacture thereof" rapid disintegrating oral dosage form comprising functionalized natural or synthetic calcium carbonate, at least one active ingredient, at least one disintegrant wherein said functionalized natural or synthetic calcium carbonate is a reaction product of natural or synthetic calcium carbonate with carbon dioxide and one or more acids, wherein carbon dioxide is formed in situ by treatment with acid and / or is supplied from an external source, and the tablet dissolves in less than 20 seconds when introduced into an aqueous environment.