Letermovir, solid oral pharmaceutical formulation, the use of a solid oral pharmaceutical formulation and process for the preparation of letermovir

摘要

Summary letermovir, solid oral pharmaceutical formulation, the use of a solid oral pharmaceutical formulation and process for the preparation of the present invention provides letermovir letermovir amorphous and solid pharmaceutical formulations for oral administrable formulation of this ( Immediate release).The said letermovir amorphous is suitable for immediate release formulations, when isolated from an organic solution, both for drying in a dryer rolls of said organic solution in a volatile organic solvent, in particular the acetone at a temperature of 30 u00b0 C to 60 u00b0 C and subsequent So nobly, drying of the amorphous letermovir obtained.Or isolation of said amorphous letermovir by precipitation from water miscible solvents selected among acetone or acetonitrile in excess water as antissolvente and, subsequently, filtering or centrifuging the letermovir amorphous is obtained.The formulations for immediate release of letermovir amorphous are intended for the use in methods of prophylaxis or treatment methods for diseases associated with the group of viruses of the family Herpesviridae, preferably associated with cytomegalovirus (CMV), even more preferably, Associ Adas with human cytomegalovirus (HCMV). 1 / 1, 1 / 2