The present invention relates to a novel combination comprising an androgen receptor inhibitor, for example: 4- (3- (4-cyano-3- (trifluoromethyl) phenyl) -5,5-dimethyl-4-oxo- 2-thioxoimidazolidin-1-yl) -2-fluoro-n-methylbenzamide or a pharmaceutically acceptable salt thereof and akt inhibiting compound, for example: n - {(1s) -2-amino-1 - [(3- fluorophenyl) methyl] ethyl} -5-chloro-4- (4-chloro-1-methyl-1h-pyrazol-5-yl) -2-thiphenecarboxamide or a pharmaceutically acceptable salt thereof and optional additional antineoplastic agents; pharmaceutical compositions comprising them and methods of using such combinations and compositions in the treatment of health conditions in which androgen receptor inhibition and / or akt inhibition is beneficial, for example, cancer.
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