method and system for reducing a solvent concentration in a plurality of microparticles, method for preparing a plurality of biodegradable microspheres with a medicinally active agent, and, composition.

摘要

embodiments may include a method for reducing a solvent concentration in a plurality of microparticles. The method may involve contacting a mixture including the plurality of microparticles and the solvent with water to form an aqueous suspension. A first portion of the solvent may dissolve in water from the aqueous suspension to reduce the solvent concentration in the plurality of microparticles from a first solvent concentration in the mixture to a second solvent concentration in the aqueous suspension. The method may also include transferring the aqueous suspension to a concentration unit which may further reduce the solvent concentration of the second solvent concentration to a third solvent concentration. The method may further include transferring a microparticle concentrate with the third solvent concentration to a wash unit to form an amalgam of microparticles washed with a fourth solvent concentration. The method may also include drying the amalgam of washed microparticles.