compound, pharmaceutical composition, method of treating a disease or condition, method of inhibiting the activity of a phosphatidylinositol 3-kinase polypeptide, method of inhibiting immune reactions or overgrowth or destructive cancer cell proliferation, kit, and, use of a compound, salt, isomer or a pharmaceutically acceptable mixture thereof.

摘要

The present application provides the compounds of formula (j), or pharmaceutically acceptable salts, isomers, tautomers or a mixture thereof, wherein n, w, a ', b', r1, r2 and r3 are described herein. The compounds are inhibitors for phosphatidylinositol 3-kinase (pi3k) activities and are useful for treating conditions mediated by one or more pi3k isoforms. The present application further provides pharmaceutical compositions which include a compound of formula (I), or pharmaceutically acceptable salts, isomers, tautomers, or mixture thereof, and methods of using these compounds and compositions for treating conditions mediated by one or more isoforms. pi3k.