magnetic resonance investigation process of a sample, preferably of a human or non-human animal body, and contrast medium.

摘要

"magnetic resonance imaging process of a sample, preferably of a human or non-human animal body, composition, contrast medium, and administrable composition." This invention provides a magnetic resonance investigation process of a sample, preferably of a human or non-human animal body, said process comprising: (i) producing a hyperpolarized solution of a high dissolution agent in a solvent physiologically tolerable a hyperpolarized solid sample of said high t-agent; (ii) wherein the hyperpolarization of the solid sample of said high t-agent in step (i) is effected by means of a polarizing agent, optionally separating the whole, substantially the whole, or a portion of said polarizing agent. said high t-agent; (iii) administering said hyperpolarized solution to said sample; (iv) exposing said sample to a second radiation of a selected frequency to stimulate nuclear gyrus transitions in the selected nuclei, for example, the high tm-1 rm imaging nuclei; (v) detecting magnetic resonance signals from said sample; and (vi) optionally imaging, dynamic flow data, perfusion data, physiological data (e.g., ph, po ~ 2 ~, pco ~ 2 ~, temperature or ionic concentrations) or metabolic data of said signals. wherein said high t-1 ~ agent in said hyperpolarized solution has a t-1 ~ value (at a field strength in the range 0.01 to 5t and a temperature in the range 20 to 40 ° c) of at minus 5 seconds.