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1.6 naftiridina - dione compounds active as suppressors of a senseless

机译:1.6 naftiridina-二酮化合物可有效抑制无意义

摘要

The Invention relates to compounds of formula (naftiridina - dione (i): Space for formula or a Salt thereof, as active suppressor missense mutation, where the substituents are as defined in the descriptive Chapter; their preparation, their use as a m Edicamento, and Medications that include.The advantage of the compounds of the invention is to promote Reading Translation taking ac50 values for the Abolition of the missense mutation between 0.4 and 22 um.
机译:本发明涉及式(naftiridina-二酮(i):作为活性抑制剂错义突变的式或其盐的空间的化合物,其中取代基如描述性章节中所定义;其制备方法,其作为Edicamento的用途和包括在内的药物。本发明化合物的优点是采用消除0.4至22 um之间的错义突变的ac50值来促进阅读翻译。

著录项

  • 公开/公告号CU20160182A7

    专利类型

  • 公开/公告日2017-03-03

    原文格式PDF

  • 申请/专利权人 NOVARTIS AG;

    申请/专利号CU20160000182

  • 申请日2015-06-02

  • 分类号A61K31/44;C07D471/04;C07D471/14;C07D495/14;

  • 国家 CU

  • 入库时间 2022-08-21 13:39:39

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