With benzyl substituted indazoles as inhibitors of BUB1, useful for the Treatment or prophylaxis of a disease hiperproliferativa and / or a Disorder that responds to the Induction of cell death, a process for the preparation of these Compounds, and compounds intermediari Os

摘要

1.1.1.1.1.2.1.1.2.2.2.2.2.2.2.2.2.2.2.2.2.2.2.2.2.2.2.2.2.1.2.1.2.2.2.2.2.2.2.2.2.1.2.2.2.2.2.2.2.2.2.2.2.2.2.2.2.2.2.2.2.2.2.2.2.2.2.2.2.2.2.1.2.2.2.2.2.2.2.2.2.2.2 This document also introduces the preparation procedure of these compounds and the intermediate compounds used in the preparation process. The new compound has better pharmacological properties, especially enhances the inhibition of bbb1 target.1. When it is used in combination with other drugs, the greater power of limiting diffusion and / or reducing drug interaction; / P