Synthesis of copanlisib, copanlisib dihydrochloride hydrate copanlisib dihydrochloride, and Intermediate compounds for their Preparation

摘要

This invention is related to a method of preparing formula (I).2. The invention method of dichloromethane hydrate, or dichlorohydrate hydrate, and intermediate preparation complex; P P frmula lt space; P P overcomes many disadvantages of the known large-scale coanliisb method; For example: the easily oxidized molecules are nitrated in batches, and the aldehyde group is converted into ammonium nitroacylate containing ammonia and iodine, which is a problem due to safety problems; the acetamide is used for epoxyclocyclocyclocyclohydroethane, which is difficult to clean up;Or the nitro group is reduced to the corresponding ammonia water containing iron and acid, which is often affected by the secondary reaction and greatly reduces its performance.